Struck on 10th Avenue near East 23rd Street shortly before 1:30 a.m. were three city residents – 32, 28 and 22 – and a 32-year-old man from Newark.
Two of them were taken to St. Joe's, and the other two arrived via private vehicles, authorities said.
Two hours later, a 38-year-old city man was shot outside the medical center near the corner of Main and Mary streets, they said.
None of the injuries were considered life-threatening, authorities said.
Another shooting outside the emergency room at St. Joe's on Thursday killed one 20-year-old city resident, Brian Olivero, and wounded another, David Torres.
Click here to follow Daily Voice Hamilton Township and receive free news updates.